Huai Er Ke Li(20g* 6 bags)HuaiEr KeLi Adjuvant therapy for Prevention of recurrence of liver cancer /JinKe

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Brand: Jin Ke

Functions and Indications: 

Suitable for healthy weakness, blood stasis, primary liver cancer is surgery and chemotherapy adjuvant treatment medicine, improve liver pain, bloating, fatigue and other symptoms. On the basis of the standard antitumor treatment of chemical drugs, it can be used to improve the quality of life of the patients with lung, stomach, and breast cancer.

Huai Er particles can be used for the treatment of liver cancer, gastric cancer, colon cancer, breast cancer and lung cancer. From the information currently available to see the effect of Huaier granule is wide, including direct apoptosis, angiogenesis of tumor cell inhibition, regulation of immunity, and these characteristics of tumor is not specific, so the treatment of other tumors can be explored. It has been reported that it is effective for esophageal cancer, bladder cancer, malignant lymphatic cancer, non Hodgkin's lymphoma, chronic myeloid leukemia, osteosarcoma, etc.

Q: Why can Huai Er particles block the recurrence of tumors?

A: The Huai Er particles are a new kind of anticancer drugs.

1. promote the apoptosis of tumor cells: the A549 cells can be prevented from entering S stage by phase G2/M, showing a sub-G1 peak before G1 peak and inducing apoptosis. But there is no side effect of chemotherapeutic drugs. On human colorectal cancer HR8348 cells can inhibit the growth and induce apoptosis and its possible mechanism of inducing apoptosis and Bak/ Bcl-2, Bak/ Bcl-XL ratio increased and upregulation of p53 gene expression. In the study of PS-T inhibited the growth of pancreatic cancer cells metastasis was observed in the PS-T and human pancreatic cancer cell co culture, cell apoptosis rate was 15% ~ 20%, better than 5-Fu, the expression and regulation of apoptosis promoting effect of apoptosis gene Caspase-3.

2. anti angiogenic effects: tumor angiogenesis by vascular endothelial cells, tumor cells and their microenvironment interaction result; is an important factor in tumor growth, invasion and metastasis. When the concentration of 0.1-10g/L was inhibited by VEGF, the proliferation of endothelial cells was inhibited significantly and dose effect relationship was found. Matrigel assay showed that HUVECs differentiated into PS-T concentration of 1.0g/L can inhibit VEGF induced tube like structure; when the concentration of 10.0g/L, HUVECs is completely blocked in vitro differentiation into tube like structure. It is believed that the extract of the herb has inhibitory effect on the construction of vascular endothelial cells in vitro, and the mechanism may be related to blocking endothelial cells from S phase into G2/M phase. The growth of human high metastatic large cell lung cancer L9981 cells was inhibited in vitro, and the inhibition rate increased with the increase of drug concentration. PS-T group (1g/L) and DDP group (cisplatin 3 mg/L) and combination group (PS-T 0.05 g/L and cisplatin 1.5 mg/L) inhibitory rate was no significant difference (P > 0.05). Clear paste treated by Huaier, L9981 cells, E-cadherin, TIMP-1, -catenin endostatin, MMP-2 mRNA expression level increased, while the VEGF, CD44V6 expression, TIMP-1 and endostatin expression levels were significantly up-regulated the expression level of CD44V6 was significantly reduced. The inhibitory effect of the compound L9981 on the growth of mRNA may be related to its regulation of angiogenesis related gene expression.

3. on chemotherapy sensitization and reverse drug resistance: PS-T in addition to its pro apoptotic effect, and also to the chemotherapy drugs used in combination to the sensitization and reverse drug resistance. It is found that the sensitivity of cisplatin to chemotherapy of cisplatin can be improved by increasing the apoptosis of cisplatin on A549DDP. According to the fluorescence quantitative PCR method, the small dose of the particle can reduce the expression of the drug resistant gene MDR-1 of the adriamycin resistant breast cancer cell line MCF-7/ADM, indicating that the inhibition of the function and expression of P2 glycoprotein (P-gp) in the cell membrane and the increase of the intracellular drug concentration are the main mechanism for the reversal of the multidrug resistance of the granules. The study found that PS-T can significantly enhance tumor necrosis factor related apoptosis inducing ligand (TRAIL) on HepG2 cells and hepatocellular carcinoma cell line HepG2-ADM resistant to adriamycin cytotoxicity, but the killing effect on normal liver cell line L02 minor.

4. regulate body immunity: modern medicine believes that the body can kill tumor cells under the synergy of cellular immunity and humoral immunity. The biological treatment of cancer is to stimulate and mobilize the immune system of the body, enhance the ability of the microenvironment to resist cancer, thereby controlling and killing tumor cells. It is found that the extract of the Huai Ercan significantly increase the number of IL-2 receptor positive cells in the liver and enhance the specific cellular immunity of the body. Improve chronic myelogenous leukemia with Huaier granule can be (CML) in patients with IL-2, TNF- alpha, INF- levels, reduce the immune suppression factor SIL-2R levels, thereby promoting tumor immunity of organism. But unlike the cytokine therapy is that PS-T induced IFN (alpha, gamma), IL-2 and other cytokines is endogenous, with small dose, and the combined effects of the characteristics of multiple stimuli. Therefore, compared with other polysaccharides, the fungus has unique characteristics, and is an ideal immunomodulator and tumor inhibitor.

5. safety and innocuity: the acute toxicity test was equivalent to 126.6 times of the common clinical dose, and the rats were measured at 95 times of LD50. In the long-term toxicity test, the rats were given 95 times the clinical dose of the stomach for 3 months, the small dose group of the dog was the clinical equivalent dose, the large dose group was 24.7 times continued for 6 months and the drug caused disease was not found. The results showed that the particle was safe.

6. granule preparation, convenient to use.

Q: How to use the granules correctly ?

A: See just to solve a variety of factors for the current lack of treatment of cancer treatment due to various reasons in effectively compensate for these features and functions from above Huaier Granule experiments, so as to effectively block the recurrence. The first is the combination of chemotherapy and chemotherapy. Chemotherapy mainly at S stage, and Huaier Granule in stage G1 and stage S have a very good performance, the G1 phase of Huaier granule and chemotherapy S period two at the same time, has good synergy, should be better than chemotherapy alone. After the end of chemotherapy, it is still necessary to insist on long-term use of black ear particles. Another method is to treat the tumor cells in the dormant state for a long time after the end of chemotherapy. If it can not be used for a long time due to various reasons, it must also be used for 6 consecutive months per year, so as to ensure the curative effect. Several clinical trials confirm that this method is correct. Long term and standardized use of the particle is the key, because the tumor is not a local disease, but the whole body disease, gene disease, WHO recently more clearly pointed out that the tumor is a chronic disease, so only a long time standard use can change the oncogene, can effectively block the recurrence.

Composition: huái ěr cream (Trametes robiniophila Murr)

Dosage and Administration: To take orally, 20g per time; 3 times daily. The adjuvant treatment of liver cancer is 1 courses/ a month, or according to the doctor's advice. Adjuvant therapy for lung cancer, gastrointestinal cancer and breast cancer is a course of six weeks.

Cautions:

1.Not for use during pregnancy.

2,Some patients have nausea and vomiting .

Storage : Store (keep) in a cool and dry place,protect from light (heat).

商品名称:槐耳颗粒(金克)

  拼音全码:HuaiErKeLi(JinKe)

【主要成份】 槐耳清膏

【性 状】 棕黄色或棕褐色颗粒;气腥,味甜,微苦。

【适应症/功能主治】 扶正固本,活血消症。适用于正气虚弱,瘀血阻滞,原发性肝癌不宜手术和化疗者辅助治疗用药,有改善肝区疼痛、腹胀、乏力等症状的作用。在标准的化学药品抗癌治疗的基础上,可用于肺癌、胃肠癌、乳腺癌所致的神疲乏力、少气懒言、脘腹疼痛或胀闷、纳谷少馨、大便干结或溏泄、或气促、咳嗽、多痰、面色晄白、胸胁不适等症,改善患者生活质量。

【规格型号】 20g*6袋

【用法用量】 口服。一次20g,一日3次。肝癌的辅助治疗一个月为1个疗程,或遵医嘱。肺癌、胃肠癌和乳腺癌的辅助治疗六周为一个疗程。

【不良反应】 个别患者出现恶心,呕吐。

【禁 忌】 尚不明确。

【注意事项】 尚不明确。 
请仔细阅读说明书并遵医嘱使用。

【药物相互作用】 如与其他药物同时使用可能会发生药物相互作用,详情请咨询医师或药师。

【贮 藏】 密闭,防潮。

【包 装】 复合铝塑薄膜。每盒装6包。

【有 效 期】 24 月

【批准文号】 国药准字Z20000109

【生产企业】 启东盖天力药业有限公司